Carbamazepine-Induced Hematological and Immunological Alterations in Egyptian Children with Idiopathic Generalized Seizures

Abstract Carbamazepine (CBZ) is one of the oldest antiepileptic drugs (AEDs) that still used for treatment tonic-clonic seizures in children. Long-term use AEDs induces potential toxic effects may remain undetermined a long time. Earlier studies have revealed wide spectrum hematological toxicities associated with CBZ. This study was conducted to unveil carbamazepine as an monotherapy on and immunological parameters group Egyptian pediatric patients using it different durations. Fifty epileptics either sex were enrolled; 38 taking CBZ ≥ 6 months 12 newly diagnosed untreated patients. Hematological studied compared their age sex-matched 15 controls among groups. found more total leukocyte count, lymphocyte serum IgA IgM levels (p < 0.001, respectively). Hemoglobin level, platelets C4 level negatively correlated (Spearman's rho = – 0.62, 0.42, 0.34, 0.13; p 0.008, 0.04, 0.44, duration inversely platelets, lymphocyte, eosinophil counts 0.03, 0.01, Epileptic children had hematologic immunologic systems affected, which mandates routine monitoring these